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Restylane has safely been used worldwide by dermatologists and plastic surgeons since 1996. Because Restylane is non-animal-based and fully biocompatible, allergy testing is not required. This quality virtually eliminates any risk of animal-based disease or allergic reaction. The most commonly reported side effects were temporary redness and swelling at the injection site. These effects typically resolve within two to three days.
Restylane is FDA approved for use in the United States. It is only currently indicated for the correction of moderate to severe facial wrinkles and folds.

Restylane lasts about twice as long as bovine collagen, so treatments are typically scheduled twice a year. Evidence shows that having a touch-up treatment before the product has fully dissipated will enhance the lasting effect.


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