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Both are steroids. As to their potency or difference, it really depends on so many factors. it maybe more potent for one but less so on another. The preparation of the drug has also something to say. If given in the injectable form, the effect can be seen faster as compared if given topically as creams or ointments. But it really depends on what the drug is being used for.Steroids especially the topicals are grouped together according to their potency, 1 being the most potent and 7 the least or the mildest. Mometasone and Fluticasone are both in the upper echelon of topical steroids.Nasonex and Flonase(fluticasone), though are nasal sprays and it really depends on the doctors choice as which product to prescribe since they can both work in similar ways.

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